Enables identical protein binding activity. Predicted to be involved in lipid catabolic process. Predicted to act upstream of or within gene expression. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for IAH1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = IAH1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of IAH1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:9,177,942–9,178,829 | 295.4 kb | Distal (>10kb) Multiome | 196 | |
| chr2:9,205,968–9,208,238 | 267.1 kb | Distal (>10kb) Multiome | 800 | |
| chr2:9,218,015–9,218,554 | 255.6 kb | Distal (>10kb) Multiome | 107 | |
| chr2:9,422,555–9,424,057 | 50.3 kb | Distal (>10kb) Multiome | 1016 | |
| chr2:9,473,505–9,475,238 | 902 bp | At TSS Multiome | 602 | |
| chr2:9,475,498–9,477,288 | 2.9 kb | Proximal (<10kb) Multiome | 228 | |
| chr2:9,554,934–9,556,567 | 82.1 kb | Distal (>10kb) Multiome | 1091 | |
| chr2:9,630,002–9,631,663 | 157.2 kb | Distal (>10kb) Multiome | 995 | |
| chr2:9,770,260–9,771,096 | 296.8 kb | Distal (>10kb) Multiome | 321 |
Genomic view of the IAH1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.