This gene encodes a protein localized to the cytoplasm. Mutations in this gene are associated with hydrolethalus syndrome. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Oct 2008]
Transcription factors with Perturb-seq knockdown data for HYLS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = HYLS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of HYLS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:125,443,557–125,444,361 | 443.7 kb | Distal (>10kb) Multiome HiCAR | 142 | |
| chr11:125,591,812–125,593,372 | 295.0 kb | Distal (>10kb) Multiome HiCAR | 902 | |
| chr11:125,625,323–125,626,856 | 261.6 kb | Distal (>10kb) Multiome | 1108 | |
| chr11:125,886,970–125,888,478 | 138 bp | At TSS Multiome | 823 | |
| chr11:125,902,922–125,903,413 | 15.5 kb | Distal (>10kb) Multiome | 495 | |
| chr11:125,904,107–125,904,760 | 16.8 kb | Distal (>10kb) Multiome | 235 | |
| chr11:125,938,819–125,939,449 | 51.4 kb | Distal (>10kb) Multiome | 161 | |
| chr11:125,941,709–125,942,323 | 54.5 kb | Distal (>10kb) Multiome | 270 | |
| chr11:126,061,736–126,063,712 | 175.4 kb | Distal (>10kb) Multiome | 802 | |
| chr11:126,082,403–126,083,132 | 195.0 kb | Distal (>10kb) Multiome | 134 | |
| chr11:126,104,267–126,104,892 | 216.9 kb | Distal (>10kb) Multiome | 192 | |
| chr11:126,159,698–126,160,582 | 272.4 kb | Distal (>10kb) Multiome | 281 |
Genomic view of the HYLS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.