This gene encodes a voltage-gated protein channel protein expressed more highly in certain cells of the immune system. Phagocytic cells produce superoxide anions which require this channel protein, and in B cells this same process facilitates antibody production. This same channel protein, however, can also regulate functions in other cells including spermatozoa. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
Transcription factors with Perturb-seq knockdown data for HVCN1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = HVCN1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of HVCN1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:110,403,190–110,403,822 | 285.4 kb | Distal (>10kb) Multiome | 779 | |
| chr12:110,431,453–110,431,925 | 257.5 kb | Distal (>10kb) Multiome | 461 | |
| chr12:110,449,732–110,450,544 | 238.8 kb | Distal (>10kb) Multiome | 883 | |
| chr12:110,468,018–110,469,597 | 219.8 kb | Distal (>10kb) Multiome | 1093 | |
| chr12:110,501,642–110,502,585 | 187.0 kb | Distal (>10kb) Multiome | 1115 | |
| chr12:110,582,284–110,583,969 | 105.8 kb | Distal (>10kb) Multiome | 740 | |
| chr12:110,613,705–110,614,482 | 75.1 kb | Distal (>10kb) Multiome | 791 | |
| chr12:110,688,496–110,690,180 | 165 bp | At TSS Multiome | 414 | |
| chr12:110,698,346–110,698,760 | 9.2 kb | Proximal (<10kb) | 491 | |
| chr12:110,742,238–110,743,370 | 53.9 kb | Distal (>10kb) Multiome | 801 | |
| chr12:110,772,664–110,773,461 | 83.9 kb | Distal (>10kb) Multiome | 88 | |
| chr12:110,846,588–110,847,239 | 157.8 kb | Distal (>10kb) Multiome | 371 | |
| chr12:110,860,936–110,861,527 | 172.1 kb | Distal (>10kb) Multiome | 127 | |
| chr12:110,936,931–110,937,646 | 248.2 kb | Distal (>10kb) Multiome | 373 |
Genomic view of the HVCN1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.