HSPA9

heat shock protein family A (Hsp70) member 9 | GRP75, PBP74, mot-2, mthsp75, HSPA9B

This gene encodes a member of the heat shock protein 70 gene family. The encoded protein is primarily localized to the mitochondria but is also found in the endoplasmic reticulum, plasma membrane and cytoplasmic vesicles. This protein is a heat-shock cognate protein. This protein plays a role in cell proliferation, stress response and maintenance of the mitochondria. A pseudogene of this gene is found on chromosome 2.[provided by RefSeq, May 2010]

Member of: DE-1 DE-1.28 Developmental clusters: GC4

Biological processes 52 terms

ATP binding (GO:0005524)ATP hydrolysis activity (GO:0016887)ATP hydrolysis activity (GO:0016887)ATP hydrolysis activity (GO:0016887)MIB complex (GO:0140275)RNA binding (GO:0003723)SAM complex (GO:0001401)calcium import into the mitochondrion (GO:0036444)calcium import into the mitochondrion (GO:0036444)cellular response to interleukin-1 (GO:0071347)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytoplasm (GO:0005737)enzyme binding (GO:0019899)erythrocyte differentiation (GO:0030218)extracellular exosome (GO:0070062)fibroblast growth factor binding (GO:0017134)focal adhesion (GO:0005925)heat shock protein binding (GO:0031072)heat shock protein binding (GO:0031072)inner mitochondrial membrane organization (GO:0007007)intracellular protein transport (GO:0006886)iron-sulfur cluster assembly (GO:0016226)iron-sulfur cluster assembly (GO:0016226)iron-sulfur cluster assembly (GO:0016226)mitochondrial inner membrane (GO:0005743)mitochondrial matrix (GO:0005759)mitochondrial matrix (GO:0005759)mitochondrial matrix (GO:0005759)mitochondrial nucleoid (GO:0042645)mitochondrion (GO:0005739)mitochondrion (GO:0005739)mitochondrion (GO:0005739)mitochondrion (GO:0005739)mitochondrion (GO:0005739)negative regulation of apoptotic process (GO:0043066)negative regulation of erythrocyte differentiation (GO:0045647)negative regulation of hematopoietic stem cell differentiation (GO:1902037)negative regulation of hemopoiesis (GO:1903707)nucleolus (GO:0005730)protein binding (GO:0005515)protein folding (GO:0006457)protein folding chaperone (GO:0044183)protein refolding (GO:0042026)protein-folding chaperone binding (GO:0051087)regulation of erythrocyte differentiation (GO:0045646)response to folic acid (GO:0051593)response to thyroxine (GO:0097068)response to toxic substance (GO:0009636)ubiquitin protein ligase binding (GO:0031625)unfolded protein binding (GO:0051082)unfolded protein binding (GO:0051082)

Expression (TPM)

TFs regulating HSPA9 0 TFs

Transcription factors with Perturb-seq knockdown data for HSPA9. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = HSPA9 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to HSPA9

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of HSPA9, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr5:138,331,426–138,332,354	243.5 kb	Distal (>10kb) Multiome	686
chr5:138,337,358–138,339,397	237.3 kb	Distal (>10kb) Multiome	1134
chr5:138,352,125–138,353,730	222.8 kb	Distal (>10kb) Multiome	868
chr5:138,438,317–138,439,353	136.5 kb	Distal (>10kb) Multiome	421
chr5:138,449,690–138,450,452	125.3 kb	Distal (>10kb) Multiome	486
chr5:138,463,424–138,467,199	110.3 kb	Distal (>10kb) Multiome	1117
chr5:138,489,025–138,489,656	86.1 kb	Distal (>10kb) Multiome	185
chr5:138,491,730–138,492,628	83.3 kb	Distal (>10kb) Multiome	627
chr5:138,542,539–138,543,997	32.1 kb	Distal (>10kb) Multiome	973
chr5:138,574,967–138,576,411	255 bp	At TSS Multiome	1066
chr5:138,579,340–138,579,536	3.9 kb	Proximal (<10kb)	205
chr5:138,725,045–138,725,717	150.0 kb	Distal (>10kb) Multiome	421
chr5:138,752,374–138,754,155	177.9 kb	Distal (>10kb) Multiome	816
chr5:139,273,424–139,274,448	698.6 kb	Distal (>10kb) Multiome HiCAR	843
chr5:139,378,115–139,378,885	803.0 kb	Distal (>10kb) Multiome HiCAR	122

Genome Browser

Genomic view of the HSPA9 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.