Predicted to enable ATP binding activity. Predicted to act upstream of or within several processes, including import into nucleus; liver development; and macrophage activation. Located in extracellular exosome. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for HSPA12A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = HSPA12A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of HSPA12A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:116,608,834–116,610,180 | 239.9 kb | Distal (>10kb) Multiome | 307 | |
| chr10:116,627,107–116,628,019 | 222.1 kb | Distal (>10kb) Multiome | 282 | |
| chr10:116,629,218–116,630,194 | 220.1 kb | Distal (>10kb) Multiome | 56 | |
| chr10:116,669,744–116,670,994 | 179.5 kb | Distal (>10kb) Multiome | 324 | |
| chr10:116,737,640–116,737,833 | 4.8 kb | Proximal (<10kb) | 47 | |
| chr10:116,741,030–116,743,588 | 107.0 kb | Distal (>10kb) Multiome | 566 | |
| chr10:116,833,883–116,834,686 | 15.5 kb | Distal (>10kb) Multiome | 209 | |
| chr10:116,836,058–116,836,660 | 13.4 kb | Distal (>10kb) Multiome | 190 | |
| chr10:116,848,918–116,850,542 | 90 bp | At TSS Multiome | 543 | |
| chr10:117,004,546–117,006,106 | 155.6 kb | Distal (>10kb) Multiome | 880 | |
| chr10:117,134,080–117,135,217 | 284.9 kb | Distal (>10kb) Multiome | 216 | |
| chr10:117,136,768–117,138,029 | 287.5 kb | Distal (>10kb) Multiome | 337 | |
| chr10:117,138,997–117,141,025 | 289.7 kb | Distal (>10kb) Multiome | 182 | |
| chr10:117,159,202–117,159,932 | 309.9 kb | Distal (>10kb) Multiome HiCAR | 133 | |
| chr10:117,162,523–117,164,008 | 313.5 kb | Distal (>10kb) Multiome HiCAR | 315 | |
| chr10:117,165,627–117,166,409 | 316.3 kb | Distal (>10kb) Multiome HiCAR | 272 | |
| chr10:117,167,701–117,168,673 | 318.6 kb | Distal (>10kb) Multiome HiCAR | 441 |
Genomic view of the HSPA12A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.