There are at least two isozymes of the corticosteroid 11-beta-dehydrogenase, a microsomal enzyme complex responsible for the interconversion of cortisol and cortisone. The type I isozyme has both 11-beta-dehydrogenase (cortisol to cortisone) and 11-oxoreductase (cortisone to cortisol) activities. The type II isozyme, encoded by this gene, has only 11-beta-dehydrogenase activity. In aldosterone-selective epithelial tissues such as the kidney, the type II isozyme catalyzes the glucocorticoid cortisol to the inactive metabolite cortisone, thus preventing illicit activation of the mineralocorticoid receptor. In tissues that do not express the mineralocorticoid receptor, such as the placenta and testis, it protects cells from the growth-inhibiting and/or pro-apoptotic effects of cortisol, particularly during embryonic development. Mutations in this gene cause the syndrome of apparent mineralocorticoid excess and hypertension. [provided by RefSeq, Feb 2010]
Transcription factors with Perturb-seq knockdown data for HSD11B2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = HSD11B2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of HSD11B2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:67,149,282–67,151,406 | 279.9 kb | Distal (>10kb) Multiome | 693 | |
| chr16:67,154,687–67,155,820 | 275.2 kb | Distal (>10kb) Multiome | 593 | |
| chr16:67,160,628–67,161,206 | 269.6 kb | Distal (>10kb) Multiome | 524 | |
| chr16:67,162,969–67,163,815 | 267.2 kb | Distal (>10kb) Multiome | 238 | |
| chr16:67,169,105–67,171,287 | 261.1 kb | Distal (>10kb) Multiome | 813 | |
| chr16:67,173,849–67,174,861 | 256.3 kb | Distal (>10kb) Multiome | 809 | |
| chr16:67,177,863–67,178,664 | 252.4 kb | Distal (>10kb) Multiome | 544 | |
| chr16:67,183,333–67,184,856 | 246.8 kb | Distal (>10kb) Multiome | 886 | |
| chr16:67,185,256–67,185,693 | 245.1 kb | Distal (>10kb) Multiome | 740 | |
| chr16:67,191,949–67,192,449 | 238.5 kb | Distal (>10kb) Multiome | 781 | |
| chr16:67,198,940–67,200,211 | 230.9 kb | Distal (>10kb) Multiome | 325 | |
| chr16:67,226,487–67,227,575 | 203.6 kb | Distal (>10kb) Multiome | 909 | |
| chr16:67,236,439–67,237,267 | 193.9 kb | Distal (>10kb) Multiome | 195 | |
| chr16:67,245,855–67,247,890 | 183.1 kb | Distal (>10kb) Multiome | 1077 | |
| chr16:67,248,206–67,249,338 | 181.6 kb | Distal (>10kb) Multiome | 467 | |
| chr16:67,262,177–67,262,869 | 168.2 kb | Distal (>10kb) Multiome | 24 | |
| chr16:67,278,724–67,279,792 | 151.2 kb | Distal (>10kb) Multiome | 869 | |
| chr16:67,326,413–67,327,343 | 103.8 kb | Distal (>10kb) Multiome | 585 | |
| chr16:67,393,199–67,393,789 | 37.1 kb | Distal (>10kb) Multiome | 377 | |
| chr16:67,396,006–67,396,718 | 34.2 kb | Distal (>10kb) Multiome | 375 | |
| chr16:67,399,230–67,399,872 | 31.1 kb | Distal (>10kb) Multiome | 211 | |
| chr16:67,415,996–67,416,812 | 14.2 kb | Distal (>10kb) Multiome | 687 | |
| chr16:67,428,012–67,428,783 | 2.3 kb | Proximal (<10kb) Multiome | 382 | |
| chr16:67,430,407–67,432,610 | 471 bp | At TSS Multiome | 790 | |
| chr16:67,480,508–67,481,841 | 50.6 kb | Distal (>10kb) Multiome | 1002 | |
| chr16:67,521,086–67,521,812 | 90.8 kb | Distal (>10kb) Multiome | 775 | |
| chr16:67,528,470–67,529,464 | 98.2 kb | Distal (>10kb) Multiome | 641 | |
| chr16:67,537,215–67,538,620 | 107.4 kb | Distal (>10kb) Multiome | 560 | |
| chr16:67,561,597–67,563,672 | 131.7 kb | Distal (>10kb) Multiome | 1044 | |
| chr16:67,644,719–67,645,304 | 214.3 kb | Distal (>10kb) Multiome | 638 | |
| chr16:67,649,353–67,649,999 | 219.1 kb | Distal (>10kb) Multiome | 112 | |
| chr16:67,652,610–67,653,810 | 222.3 kb | Distal (>10kb) Multiome | 498 | |
| chr16:67,659,631–67,661,707 | 230.2 kb | Distal (>10kb) Multiome | 962 | |
| chr16:67,666,180–67,667,235 | 236.0 kb | Distal (>10kb) Multiome | 713 | |
| chr16:67,667,674–67,668,349 | 237.4 kb | Distal (>10kb) Multiome | 628 | |
| chr16:67,718,772–67,720,138 | 288.7 kb | Distal (>10kb) Multiome | 866 |
Genomic view of the HSD11B2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.