This gene encodes a member of the BCL-2 protein family. Members of this family are involved in activating or inhibiting apoptosis. The encoded protein localizes to intracellular membranes. This protein promotes apoptosis by interacting with the apoptotic inhibitors BCL-2 and BCL-X(L) via its BH3 domain. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2012]
Transcription factors with Perturb-seq knockdown data for HRK. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = HRK upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of HRK, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:116,737,743–116,738,634 | 142.9 kb | Distal (>10kb) Multiome | 852 | |
| chr12:116,818,976–116,819,922 | 61.6 kb | Distal (>10kb) Multiome | 760 | |
| chr12:116,876,126–116,876,628 | 4.6 kb | Proximal (<10kb) Multiome | 82 | |
| chr12:116,880,733–116,881,665 | 151 bp | At TSS Multiome | 509 | |
| chr12:116,910,746–116,911,448 | 30.0 kb | Distal (>10kb) Multiome | 902 | |
| chr12:117,098,887–117,099,725 | 218.3 kb | Distal (>10kb) Multiome | 608 | |
| chr12:117,155,214–117,156,022 | 274.4 kb | Distal (>10kb) Multiome | 507 |
Genomic view of the HRK locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.