HPSE2

heparanase 2 (inactive) | HPA2, HPR2, UFS

This gene encodes a heparanase enzyme. The encoded protein is a endoglycosidase that degrades heparin sulfate proteoglycans located on the extracellular matrix and cell surface. This protein may be involved in biological processes involving remodeling of the extracellular matrix including angiogenesis and tumor progression. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

Biological processes 12 terms

extracellular matrix (GO:0031012)extracellular matrix (GO:0031012)extracellular matrix organization (GO:0030198)extracellular region (GO:0005576)heparan sulfate proteoglycan binding (GO:0043395)heparan sulfate proteoglycan catabolic process (GO:0030200)heparanase activity (GO:0030305)heparanase activity (GO:0030305)hydrolase activity, acting on glycosyl bonds (GO:0016798)membrane (GO:0016020)plasma membrane (GO:0005886)protein sequestering activity (GO:0140311)

Expression (TPM)

TFs regulating HPSE2 0 TFs

Transcription factors with Perturb-seq knockdown data for HPSE2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = HPSE2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to HPSE2

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of HPSE2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr10:98,446,188–98,447,219	297.2 kb	Distal (>10kb) Multiome	725
chr10:98,467,326–98,468,343	276.4 kb	Distal (>10kb) Multiome HiCAR	539
chr10:98,559,915–98,560,656	183.8 kb	Distal (>10kb) Multiome	57
chr10:98,601,370–98,602,074	142.4 kb	Distal (>10kb) Multiome	96
chr10:98,620,457–98,621,138	123.4 kb	Distal (>10kb) Multiome	169
chr10:98,647,080–98,647,812	96.6 kb	Distal (>10kb) Multiome	159
chr10:98,748,408–98,748,573	4.3 kb	Proximal (<10kb)	27
chr10:99,266,221–99,266,995	522.5 kb	Distal (>10kb) Multiome HiCAR	113

Genome Browser

Genomic view of the HPSE2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.