Enables DNA binding activity and nucleosome binding activity. Involved in several processes, including cellular response to hypoxia; heterochromatin organization; and regulation of nucleus size. Located in chromosome and nuclear speck. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for HP1BP3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = HP1BP3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of HP1BP3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:20,486,131–20,487,438 | 299.8 kb | Distal (>10kb) Multiome | 760 | |
| chr1:20,493,822–20,494,241 | 292.5 kb | Distal (>10kb) Multiome | 430 | |
| chr1:20,507,717–20,508,432 | 278.5 kb | Distal (>10kb) Multiome | 811 | |
| chr1:20,552,019–20,553,890 | 234.3 kb | Distal (>10kb) Multiome | 518 | |
| chr1:20,588,675–20,590,358 | 197.6 kb | Distal (>10kb) Multiome | 431 | |
| chr1:20,625,186–20,625,881 | 161.2 kb | Distal (>10kb) Multiome | 123 | |
| chr1:20,633,024–20,634,989 | 152.8 kb | Distal (>10kb) Multiome | 759 | |
| chr1:20,661,099–20,662,130 | 125.1 kb | Distal (>10kb) Multiome | 784 | |
| chr1:20,696,319–20,697,384 | 89.8 kb | Distal (>10kb) Multiome | 727 | |
| chr1:20,717,384–20,718,370 | 68.8 kb | Distal (>10kb) Multiome | 440 | |
| chr1:20,731,726–20,733,330 | 54.4 kb | Distal (>10kb) Multiome | 718 | |
| chr1:20,786,021–20,787,857 | 320 bp | At TSS Multiome | 963 | |
| chr1:20,790,988–20,791,280 | 4.3 kb | Proximal (<10kb) | 24 |
Genomic view of the HP1BP3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.