HOOK2

hook microtubule tethering protein 2 | HK2

Hook proteins are cytosolic coiled-coil proteins that contain conserved N-terminal domains, which attach to microtubules, and more divergent C-terminal domains, which mediate binding to organelles. The Drosophila Hook protein is a component of the endocytic compartment.[supplied by OMIM, Apr 2004]

Member of: DE-5 DE-5.1

Biological processes 33 terms

FHF complex (GO:0070695)FHF complex (GO:0070695)Golgi apparatus (GO:0005794)HOPS complex (GO:0030897)centrosome (GO:0005813)centrosome (GO:0005813)centrosome (GO:0005813)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytoplasmic microtubule organization (GO:0031122)cytoplasmic microtubule organization (GO:0031122)cytoskeleton (GO:0005856)cytoskeleton-dependent intracellular transport (GO:0030705)cytoskeleton-dependent intracellular transport (GO:0030705)cytosol (GO:0005829)dynein light intermediate chain binding (GO:0051959)early endosome to late endosome transport (GO:0045022)early endosome to late endosome transport (GO:0045022)endocytosis (GO:0006897)endosome organization (GO:0007032)endosome organization (GO:0007032)endosome to lysosome transport (GO:0008333)endosome to lysosome transport (GO:0008333)identical protein binding (GO:0042802)lysosome organization (GO:0007040)lysosome organization (GO:0007040)microtubule binding (GO:0008017)microtubule binding (GO:0008017)protein binding (GO:0005515)protein localization to perinuclear region of cytoplasm (GO:1905719)protein localization to perinuclear region of cytoplasm (GO:1905719)protein transport along microtubule (GO:0098840)trans-Golgi network (GO:0005802)

Expression (TPM)

TFs regulating HOOK2 0 TFs

Transcription factors with Perturb-seq knockdown data for HOOK2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = HOOK2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to HOOK2

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of HOOK2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr19:12,484,131–12,485,387	290.7 kb	Distal (>10kb) Multiome	664
chr19:12,495,009–12,495,882	280.1 kb	Distal (>10kb) Multiome	824
chr19:12,550,951–12,551,971	224.0 kb	Distal (>10kb) Multiome	976
chr19:12,571,455–12,571,942	203.9 kb	Distal (>10kb) Multiome	36
chr19:12,610,516–12,611,613	164.6 kb	Distal (>10kb) Multiome	925
chr19:12,639,899–12,640,614	135.3 kb	Distal (>10kb) Multiome	454
chr19:12,647,538–12,648,022	127.8 kb	Distal (>10kb) Multiome	126
chr19:12,656,871–12,657,566	118.4 kb	Distal (>10kb) Multiome	254
chr19:12,666,317–12,667,225	108.8 kb	Distal (>10kb) Multiome	495
chr19:12,669,351–12,669,939	106.0 kb	Distal (>10kb) Multiome	777
chr19:12,681,003–12,682,117	94.1 kb	Distal (>10kb) Multiome	994
chr19:12,696,035–12,696,970	78.9 kb	Distal (>10kb) Multiome	806
chr19:12,702,968–12,703,602	72.3 kb	Distal (>10kb) Multiome	121
chr19:12,721,692–12,723,084	53.1 kb	Distal (>10kb) Multiome	807
chr19:12,723,726–12,724,142	51.5 kb	Distal (>10kb) Multiome	539
chr19:12,734,221–12,735,284	40.8 kb	Distal (>10kb) Multiome	882
chr19:12,736,470–12,737,780	38.4 kb	Distal (>10kb) Multiome	742
chr19:12,757,454–12,758,297	17.8 kb	Distal (>10kb) Multiome	588
chr19:12,765,876–12,766,545	9.3 kb	Proximal (<10kb) Multiome	557
chr19:12,769,704–12,770,031	5.5 kb	Proximal (<10kb)	143
chr19:12,774,659–12,776,025	144 bp	At TSS Multiome	803
chr19:12,777,481–12,778,589	2.3 kb	Proximal (<10kb) Multiome	661
chr19:12,779,150–12,779,467	3.6 kb	Proximal (<10kb)	316
chr19:12,782,418–12,783,038	7.2 kb	Proximal (<10kb) Multiome	699
chr19:12,789,543–12,790,654	14.5 kb	Distal (>10kb) Multiome	717
chr19:12,790,960–12,793,231	16.0 kb	Distal (>10kb) Multiome	1015
chr19:12,793,340–12,794,240	18.1 kb	Distal (>10kb) Multiome	808
chr19:12,801,120–12,802,290	26.4 kb	Distal (>10kb) Multiome	901
chr19:12,806,212–12,806,984	31.0 kb	Distal (>10kb) Multiome	827
chr19:12,825,565–12,826,186	50.3 kb	Distal (>10kb) Multiome	436
chr19:12,832,484–12,833,101	57.1 kb	Distal (>10kb) Multiome	970
chr19:12,833,638–12,834,477	58.4 kb	Distal (>10kb) Multiome	310
chr19:12,838,114–12,838,869	62.9 kb	Distal (>10kb) Multiome	377
chr19:12,840,071–12,841,485	65.3 kb	Distal (>10kb) Multiome	391
chr19:12,847,633–12,848,090	72.2 kb	Distal (>10kb) Multiome	535
chr19:12,867,327–12,868,022	92.1 kb	Distal (>10kb) Multiome	315
chr19:12,872,968–12,873,990	97.8 kb	Distal (>10kb) Multiome	263
chr19:12,880,834–12,881,875	105.9 kb	Distal (>10kb) Multiome	656
chr19:12,884,836–12,886,381	109.8 kb	Distal (>10kb) Multiome	717
chr19:12,890,614–12,891,603	115.5 kb	Distal (>10kb) Multiome	841
chr19:12,913,054–12,913,584	137.8 kb	Distal (>10kb) Multiome	373
chr19:12,919,018–12,919,719	143.8 kb	Distal (>10kb) Multiome	732
chr19:12,933,441–12,934,086	158.2 kb	Distal (>10kb) Multiome	789
chr19:12,937,426–12,939,166	162.9 kb	Distal (>10kb) Multiome	943
chr19:12,945,275–12,946,647	170.4 kb	Distal (>10kb) Multiome	1015
chr19:12,956,801–12,957,360	181.7 kb	Distal (>10kb) Multiome	747
chr19:12,964,998–12,965,862	189.9 kb	Distal (>10kb) Multiome	733
chr19:12,983,506–12,983,997	208.1 kb	Distal (>10kb) Multiome	688
chr19:13,051,485–13,052,169	276.3 kb	Distal (>10kb) Multiome	649
chr19:13,061,195–13,061,672	285.9 kb	Distal (>10kb) Multiome	544
chr19:13,069,469–13,070,306	294.3 kb	Distal (>10kb) Multiome	334

Genome Browser

Genomic view of the HOOK2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.