This gene encodes a member of the homer family of dendritic proteins. Members of this family regulate group 1 metabotrophic glutamate receptor function. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for HOMER1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = HOMER1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of HOMER1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:79,235,642–79,237,807 | 278.1 kb | Distal (>10kb) Multiome | 860 | |
| chr5:79,513,105–79,515,012 | 320 bp | At TSS Multiome | 1047 | |
| chr5:79,611,762–79,612,858 | 98.3 kb | Distal (>10kb) Multiome | 915 | |
| chr5:79,689,305–79,690,483 | 175.8 kb | Distal (>10kb) Multiome | 273 |
Genomic view of the HOMER1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.