Enables identical protein binding activity. Predicted to be involved in regulation of gene expression. Predicted to act upstream of or within negative regulation of neuron differentiation; negative regulation of protein sumoylation; and negative regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for HMG20A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = HMG20A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of HMG20A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:77,419,234–77,421,343 | 599 bp | At TSS Multiome | 941 | |
| chr15:77,496,731–77,497,500 | 76.2 kb | Distal (>10kb) Multiome | 517 | |
| chr15:77,510,024–77,510,883 | 89.6 kb | Distal (>10kb) Multiome | 121 | |
| chr15:77,525,254–77,525,853 | 104.6 kb | Distal (>10kb) Multiome | 43 | |
| chr15:77,528,312–77,529,264 | 108.0 kb | Distal (>10kb) Multiome | 100 | |
| chr15:77,543,155–77,543,857 | 122.6 kb | Distal (>10kb) Multiome | 680 | |
| chr15:77,604,253–77,604,752 | 183.7 kb | Distal (>10kb) Multiome | 145 | |
| chr15:77,623,073–77,623,871 | 202.6 kb | Distal (>10kb) Multiome | 292 | |
| chr15:77,630,922–77,631,706 | 210.4 kb | Distal (>10kb) Multiome | 92 | |
| chr15:77,632,252–77,635,007 | 213.9 kb | Distal (>10kb) Multiome | 831 |
Genomic view of the HMG20A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.