This gene encodes a member of a family of closely related, large, zinc finger-containing transcription factors. The encoded protein regulates transcription by binding to regulatory regions of various cellular and viral genes that maybe involved in growth, development and metastasis. The protein contains the ZAS domain comprised of two widely separated regions of zinc finger motifs, a stretch of highly acidic amino acids and a serine/threonine-rich sequence. [provided by RefSeq, Nov 2012]
Transcription factors with Perturb-seq knockdown data for HIVEP2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = HIVEP2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of HIVEP2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:142,926,424–142,927,518 | 18.3 kb | Distal (>10kb) Multiome | 863 | |
| chr6:142,940,466–142,940,803 | 4.3 kb | Proximal (<10kb) | 67 | |
| chr6:142,943,820–142,947,756 | 1.2 kb | Proximal (<10kb) Multiome | 1242 | |
| chr6:142,950,173–142,950,651 | 5.1 kb | Proximal (<10kb) | 97 | |
| chr6:143,060,163–143,061,516 | 115.6 kb | Distal (>10kb) Multiome | 1090 |
Genomic view of the HIVEP2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.