HIP1R

huntingtin interacting protein 1 related | FLJ14000, HIP12, HIP3, ILWEQ, KIAA0655

Enables several functions, including phosphatidylinositol phosphate binding activity; phosphatidylinositol-3,4-bisphosphate binding activity; and protein homodimerization activity. Involved in several processes, including positive regulation of signal transduction; protein stabilization; and regulation of organelle organization. Located in clathrin-coated vesicle; cytosol; and ruffle membrane. [provided by Alliance of Genome Resources, Apr 2025]

Biological processes 84 terms

SH3 domain binding (GO:0017124)actin binding (GO:0003779)actin filament binding (GO:0051015)actin filament binding (GO:0051015)actin filament binding (GO:0051015)actin filament organization (GO:0007015)apical plasma membrane (GO:0016324)apoptotic signaling pathway (GO:0097190)cell cortex (GO:0005938)clathrin binding (GO:0030276)clathrin binding (GO:0030276)clathrin coat assembly (GO:0048268)clathrin coat assembly (GO:0048268)clathrin light chain binding (GO:0032051)clathrin light chain binding (GO:0032051)clathrin-cargo adaptor activity (GO:0035615)clathrin-cargo adaptor activity (GO:0035615)clathrin-coated pit (GO:0005905)clathrin-coated vesicle (GO:0030136)clathrin-coated vesicle (GO:0030136)clathrin-coated vesicle (GO:0030136)clathrin-coated vesicle membrane (GO:0030665)cortical actin cytoskeleton (GO:0030864)cytoskeleton (GO:0005856)cytosol (GO:0005829)cytosol (GO:0005829)dendrite cytoplasm (GO:0032839)dendritic spine (GO:0043197)digestive system development (GO:0055123)endocytosis (GO:0006897)endocytosis (GO:0006897)endomembrane system (GO:0012505)glutamatergic synapse (GO:0098978)identical protein binding (GO:0042802)intrinsic apoptotic signaling pathway (GO:0097193)membrane organization (GO:0061024)negative regulation of Arp2/3 complex-mediated actin nucleation (GO:0034316)negative regulation of actin filament polymerization (GO:0030837)negative regulation of actin filament polymerization (GO:0030837)negative regulation of apoptotic process (GO:0043066)neuronal cell body (GO:0043025)perinuclear region of cytoplasm (GO:0048471)phosphatidylinositol binding (GO:0035091)phosphatidylinositol-3,4,5-trisphosphate binding (GO:0005547)phosphatidylinositol-3,4-bisphosphate binding (GO:0043325)phosphatidylinositol-3,4-bisphosphate binding (GO:0043325)phosphatidylinositol-3,4-bisphosphate binding (GO:0043325)phosphatidylinositol-3,5-bisphosphate binding (GO:0080025)phosphatidylinositol-3,5-bisphosphate binding (GO:0080025)phosphatidylinositol-3,5-bisphosphate binding (GO:0080025)phosphatidylinositol-4,5-bisphosphate binding (GO:0005546)phospholipid binding (GO:0005543)positive regulation of cellular component organization (GO:0051130)positive regulation of clathrin coat assembly (GO:1905445)positive regulation of epidermal growth factor receptor signaling pathway (GO:0045742)positive regulation of epidermal growth factor receptor signaling pathway (GO:0045742)positive regulation of epidermal growth factor receptor signaling pathway (GO:0045742)positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway (GO:1901030)positive regulation of platelet-derived growth factor receptor-beta signaling pathway (GO:2000588)positive regulation of platelet-derived growth factor receptor-beta signaling pathway (GO:2000588)positive regulation of platelet-derived growth factor receptor-beta signaling pathway (GO:2000588)positive regulation of transport (GO:0051050)postsynapse (GO:0098794)postsynapse organization (GO:0099173)postsynaptic density (GO:0014069)postsynaptic endocytic zone (GO:0098843)protein binding (GO:0005515)protein heterodimerization activity (GO:0046982)protein homodimerization activity (GO:0042803)protein homodimerization activity (GO:0042803)protein stabilization (GO:0050821)protein stabilization (GO:0050821)receptor-mediated endocytosis (GO:0006898)receptor-mediated endocytosis (GO:0006898)regulation of actin cytoskeleton organization (GO:0032956)regulation of actin cytoskeleton organization (GO:0032956)regulation of apoptotic process (GO:0042981)regulation of clathrin-dependent endocytosis (GO:2000369)regulation of endocytosis (GO:0030100)regulation of endocytosis (GO:0030100)regulation of endocytosis (GO:0030100)regulation of gastric acid secretion (GO:0060453)ruffle membrane (GO:0032587)synaptic membrane (GO:0097060)

Expression (TPM)

TFs regulating HIP1R 0 TFs

Transcription factors with Perturb-seq knockdown data for HIP1R. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = HIP1R upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to HIP1R

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of HIP1R, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr12:122,751,194–122,751,767	84.1 kb	Distal (>10kb) Multiome	128
chr12:122,752,332–122,753,299	82.7 kb	Distal (>10kb) Multiome	978
chr12:122,774,223–122,774,865	60.9 kb	Distal (>10kb) Multiome	445
chr12:122,834,656–122,836,128	51 bp	At TSS Multiome	514
chr12:122,895,832–122,896,391	60.6 kb	Distal (>10kb) Multiome	774
chr12:122,965,963–122,966,953	131.1 kb	Distal (>10kb) Multiome	576
chr12:122,974,115–122,975,704	139.4 kb	Distal (>10kb) Multiome	889
chr12:122,980,138–122,981,155	145.2 kb	Distal (>10kb) Multiome	817
chr12:123,049,639–123,050,104	214.3 kb	Distal (>10kb) Multiome	45

Genome Browser

Genomic view of the HIP1R locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.