HIF1AN

hypoxia inducible factor 1 subunit alpha inhibitor | DKFZp762F1811, FIH1, FLJ20615, FLJ22027

Enables several functions, including 2-oxoglutarate-dependent dioxygenase activity; NF-kappaB binding activity; and transition metal ion binding activity. Involved in negative regulation of Notch signaling pathway and positive regulation of myoblast differentiation. Located in cytosol; nucleoplasm; and perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Member of: DE-5

Biological processes 36 terms

NF-kappaB binding (GO:0051059)Notch binding (GO:0005112)RNA polymerase II-specific DNA-binding transcription factor binding (GO:0061629)[protein]-asparagine 3-dioxygenase activity (GO:0036140)[protein]-asparagine 3-dioxygenase activity (GO:0036140)[protein]-asparagine 3-dioxygenase activity (GO:0036140)[protein]-asparagine 3-dioxygenase activity (GO:0036140)ankyrin repeat binding (GO:0071532)carboxylic acid binding (GO:0031406)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytosol (GO:0005829)cytosol (GO:0005829)ferrous iron binding (GO:0008198)negative regulation of Notch signaling pathway (GO:0045746)negative regulation of Notch signaling pathway (GO:0045746)negative regulation of transcription by RNA polymerase II (GO:0000122)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)oxygen sensor activity (GO:0019826)peptidyl-aspartic acid 3-dioxygenase activity (GO:0062101)peptidyl-histidine dioxygenase activity (GO:0036139)peptidyl-histidine dioxygenase activity (GO:0036139)perinuclear region of cytoplasm (GO:0048471)perinuclear region of cytoplasm (GO:0048471)positive regulation of myoblast differentiation (GO:0045663)positive regulation of vasculogenesis (GO:2001214)protein binding (GO:0005515)protein homodimerization activity (GO:0042803)regulation of developmental process (GO:0050793)regulation of signal transduction (GO:0009966)regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030947)transcription corepressor activity (GO:0003714)zinc ion binding (GO:0008270)

Expression (TPM)

TFs regulating HIF1AN 0 TFs

Transcription factors with Perturb-seq knockdown data for HIF1AN. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = HIF1AN upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to HIF1AN

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of HIF1AN, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr10:100,267,386–100,267,986	268.2 kb	Distal (>10kb) Multiome	715
chr10:100,286,018–100,287,021	249.4 kb	Distal (>10kb) Multiome	849
chr10:100,346,401–100,347,640	189.1 kb	Distal (>10kb) Multiome	919
chr10:100,359,067–100,359,724	176.7 kb	Distal (>10kb) Multiome	425
chr10:100,372,854–100,374,386	162.4 kb	Distal (>10kb) Multiome	964
chr10:100,481,576–100,482,049	54.3 kb	Distal (>10kb) Multiome	298
chr10:100,482,268–100,483,078	53.1 kb	Distal (>10kb) Multiome	497
chr10:100,485,778–100,486,586	49.8 kb	Distal (>10kb) Multiome	161
chr10:100,518,832–100,519,948	16.5 kb	Distal (>10kb) Multiome	417
chr10:100,529,444–100,530,236	6.1 kb	Proximal (<10kb) Multiome	619
chr10:100,535,502–100,536,234	54 bp	At TSS Multiome	759
chr10:100,561,994–100,562,629	26.2 kb	Distal (>10kb) Multiome	491
chr10:100,654,597–100,655,452	119.2 kb	Distal (>10kb) Multiome	300
chr10:100,656,014–100,657,003	120.7 kb	Distal (>10kb) Multiome	310
chr10:100,670,865–100,671,507	135.2 kb	Distal (>10kb) Multiome	364
chr10:100,680,805–100,681,542	145.1 kb	Distal (>10kb) Multiome	636
chr10:100,715,555–100,715,963	179.9 kb	Distal (>10kb) Multiome	117
chr10:100,729,074–100,730,178	193.5 kb	Distal (>10kb) Multiome	304
chr10:100,739,174–100,740,373	203.8 kb	Distal (>10kb) Multiome	205
chr10:100,744,447–100,746,357	209.5 kb	Distal (>10kb) Multiome	379
chr10:100,760,518–100,761,080	224.9 kb	Distal (>10kb) Multiome	105
chr10:100,787,902–100,788,519	252.3 kb	Distal (>10kb) Multiome	52
chr10:100,826,838–100,828,148	292.0 kb	Distal (>10kb) Multiome	327

Genome Browser

Genomic view of the HIF1AN locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.