This gene encodes a member of the homeobox family of transcription factors, many of which are involved in developmental processes. Expression in specific hematopoietic lineages suggests that this protein may play a role in hematopoietic differentiation. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for HHEX. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = HHEX upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of HHEX, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:92,573,390–92,574,819 | 115.8 kb | Distal (>10kb) Multiome | 974 | |
| chr10:92,590,647–92,592,274 | 98.3 kb | Distal (>10kb) Multiome | 830 | |
| chr10:92,592,537–92,593,580 | 96.8 kb | Distal (>10kb) Multiome | 832 | |
| chr10:92,688,898–92,690,771 | 124 bp | At TSS Multiome | 843 | |
| chr10:92,691,602–92,693,182 | 2.7 kb | Proximal (<10kb) Multiome | 451 | |
| chr10:92,695,704–92,696,803 | 5.8 kb | Proximal (<10kb) | 353 | |
| chr10:92,699,412–92,699,875 | 9.5 kb | Proximal (<10kb) | 314 | |
| chr10:92,789,669–92,790,231 | 100.0 kb | Distal (>10kb) Multiome | 103 | |
| chr10:92,848,153–92,849,292 | 158.6 kb | Distal (>10kb) Multiome | 664 |
Genomic view of the HHEX locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.