Transcription factors with Perturb-seq knockdown data for HEXIM2-AS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = HEXIM2-AS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of HEXIM2-AS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:44,899,009–44,900,053 | 261.9 kb | Distal (>10kb) Multiome | 987 | |
| chr17:44,911,165–44,911,786 | 250.1 kb | Distal (>10kb) Multiome | 412 | |
| chr17:44,947,322–44,948,161 | 213.7 kb | Distal (>10kb) Multiome | 891 | |
| chr17:44,966,864–44,969,160 | 193.1 kb | Distal (>10kb) Multiome | 526 | |
| chr17:44,987,181–44,987,616 | 174.0 kb | Distal (>10kb) Multiome | 93 | |
| chr17:45,021,768–45,022,248 | 139.4 kb | Distal (>10kb) Multiome | 739 | |
| chr17:45,051,210–45,051,755 | 110.0 kb | Distal (>10kb) Multiome | 771 | |
| chr17:45,060,587–45,061,694 | 100.3 kb | Distal (>10kb) Multiome | 979 | |
| chr17:45,131,590–45,133,655 | 28.1 kb | Distal (>10kb) Multiome | 898 | |
| chr17:45,135,189–45,136,052 | 26.0 kb | Distal (>10kb) Multiome | 930 | |
| chr17:45,143,207–45,145,183 | 17.7 kb | Distal (>10kb) Multiome | 308 | |
| chr17:45,147,066–45,150,271 | 14.1 kb | Distal (>10kb) Multiome | 1345 | |
| chr17:45,160,688–45,162,340 | 129 bp | At TSS Multiome | 1200 | |
| chr17:45,197,493–45,198,189 | 36.4 kb | Distal (>10kb) Multiome | 835 | |
| chr17:45,241,380–45,242,217 | 80.3 kb | Distal (>10kb) Multiome | 131 | |
| chr17:45,246,828–45,248,615 | 86.2 kb | Distal (>10kb) Multiome | 858 | |
| chr17:45,261,690–45,262,406 | 100.5 kb | Distal (>10kb) Multiome | 234 | |
| chr17:45,316,202–45,317,910 | 155.6 kb | Distal (>10kb) Multiome | 857 | |
| chr17:45,334,174–45,334,847 | 172.9 kb | Distal (>10kb) Multiome | 149 | |
| chr17:45,371,481–45,372,140 | 210.3 kb | Distal (>10kb) Multiome | 704 | |
| chr17:45,395,009–45,395,645 | 233.8 kb | Distal (>10kb) Multiome | 482 | |
| chr17:45,404,953–45,406,129 | 243.9 kb | Distal (>10kb) Multiome | 244 | |
| chr17:45,425,403–45,426,061 | 264.3 kb | Distal (>10kb) Multiome | 506 | |
| chr17:45,427,967–45,428,575 | 266.7 kb | Distal (>10kb) Multiome | 454 | |
| chr17:45,429,511–45,430,237 | 268.3 kb | Distal (>10kb) Multiome | 190 | |
| chr17:45,431,253–45,432,633 | 270.2 kb | Distal (>10kb) Multiome | 435 |
Genomic view of the HEXIM2-AS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.