HELZ2
helicase with zinc finger 2 | KIAA1769, PDIP1, PRIC285

The protein encoded by this gene is a nuclear transcriptional co-activator for peroxisome proliferator activated receptor alpha. The encoded protein contains a zinc finger and is a helicase that appears to be part of the peroxisome proliferator activated receptor alpha interacting complex. This gene is a member of the DNA2/NAM7 helicase gene family. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Developmental clusters: GC6
Biological processes 23 terms
3'-5'-RNA exonuclease activity (GO:0000175)ATP hydrolysis activity (GO:0016887)P granule (GO:0043186)RNA binding (GO:0003723)RNA binding (GO:0003723)RNA binding (GO:0003723)RNA helicase activity (GO:0003724)RNA helicase activity (GO:0003724)RNA nuclease activity (GO:0004540)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytosol (GO:0005829)exoribonuclease II activity (GO:0008859)exoribonuclease II activity (GO:0008859)helicase activity (GO:0004386)membrane (GO:0016020)metal ion binding (GO:0046872)nucleoplasm (GO:0005654)nucleoplasm (GO:0005654)positive regulation of transcription by RNA polymerase II (GO:0045944)protein binding (GO:0005515)regulatory ncRNA-mediated post-transcriptional gene silencing (GO:0035194)transcription coactivator activity (GO:0003713)
Expression (TPM)
HELZ2 — as a Regulated Gene

TFs regulating HELZ2 0 TFs

Transcription factors with Perturb-seq knockdown data for HELZ2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = HELZ2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to HELZ2

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of HELZ2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr20:63,409,631–63,410,124 164.4 kb Distal (>10kb) Multiome 60
chr20:63,471,533–63,472,788 101.6 kb Distal (>10kb) Multiome 219
chr20:63,488,166–63,488,632 85.8 kb Distal (>10kb) Multiome 127
chr20:63,498,850–63,499,391 75.0 kb Distal (>10kb) Multiome 232
chr20:63,519,657–63,521,677 53.6 kb Distal (>10kb) Multiome 712
chr20:63,537,759–63,538,455 36.2 kb Distal (>10kb) Multiome 823
chr20:63,552,551–63,554,733 20.7 kb Distal (>10kb) Multiome 544
chr20:63,573,969–63,574,596 62 bp At TSS Multiome 551
chr20:63,626,480–63,627,647 52.8 kb Distal (>10kb) Multiome 982
chr20:63,641,266–63,642,913 67.8 kb Distal (>10kb) Multiome 691
chr20:63,652,233–63,654,166 79.3 kb Distal (>10kb) Multiome 1011
chr20:63,657,813–63,658,939 84.2 kb Distal (>10kb) Multiome 1055
chr20:63,707,489–63,708,488 133.7 kb Distal (>10kb) Multiome 1008
chr20:63,737,573–63,741,470 165.4 kb Distal (>10kb) Multiome 1098
chr20:63,775,216–63,775,997 201.2 kb Distal (>10kb) Multiome 257
chr20:63,830,341–63,832,721 257.1 kb Distal (>10kb) Multiome 628
chr20:63,864,234–63,865,991 290.9 kb Distal (>10kb) Multiome 1158

Genome Browser

Genomic view of the HELZ2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr20:63,399,631 – 63,875,991
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
Huangfu Lab · Publications · Resources · Contact