Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in regulation of dendrite morphogenesis and ubiquitin-dependent protein catabolic process. Predicted to be located in cytosol. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for HECW1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = HECW1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of HECW1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:42,887,741–42,889,424 | 224.2 kb | Distal (>10kb) Multiome | 819 | |
| chr7:42,911,366–42,912,538 | 200.6 kb | Distal (>10kb) Multiome | 975 | |
| chr7:42,931,754–42,932,671 | 180.3 kb | Distal (>10kb) Multiome HiCAR | 701 | |
| chr7:42,965,185–42,965,768 | 147.3 kb | Distal (>10kb) Multiome | 88 | |
| chr7:43,108,219–43,108,698 | 4.2 kb | Proximal (<10kb) Multiome | 184 | |
| chr7:43,112,283–43,114,054 | 549 bp | At TSS Multiome | 392 | |
| chr7:43,439,357–43,440,269 | 327.2 kb | Distal (>10kb) Multiome HiCAR | 289 |
Genomic view of the HECW1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.