Enables RNA binding activity. Involved in several processes, including positive regulation of RNA metabolic process; protein localization to nucleolus; and ribosomal small subunit biogenesis. Located in fibrillar center and mitochondrion. Part of small-subunit processome. Implicated in pancreatic ductal carcinoma. Biomarker of glioblastoma. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for HEATR1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = HEATR1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of HEATR1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:236,394,885–236,396,208 | 209.1 kb | Distal (>10kb) Multiome | 588 | |
| chr1:236,602,242–236,602,880 | 1.6 kb | Proximal (<10kb) | 40 | |
| chr1:236,603,983–236,605,319 | 100 bp | At TSS Multiome | 928 | |
| chr1:236,609,194–236,609,410 | 4.7 kb | Proximal (<10kb) | 115 | |
| chr1:236,685,947–236,687,221 | 81.9 kb | Distal (>10kb) Multiome | 483 | |
| chr1:236,794,715–236,796,156 | 190.7 kb | Distal (>10kb) Multiome | 1141 |
Genomic view of the HEATR1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.