This gene is a member of the host cell factor family and encodes a protein with five Kelch repeats, a fibronectin-like motif, and six HCF repeats, each of which contains a highly specific cleavage signal. This nuclear coactivator is proteolytically cleaved at one of the six possible sites, resulting in the creation of an N-terminal chain and the corresponding C-terminal chain. The final form of this protein consists of noncovalently bound N- and C-terminal chains. The protein is involved in control of the cell cycle and transcriptional regulation during herpes simplex virus infection. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for HCFC1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = HCFC1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of HCFC1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chrX:153,687,144–153,688,247 | 284.0 kb | Distal (>10kb) Multiome | 201 | |
| chrX:153,723,829–153,725,285 | 247.2 kb | Distal (>10kb) Multiome | 620 | |
| chrX:153,726,395–153,727,168 | 244.9 kb | Distal (>10kb) Multiome | 529 | |
| chrX:153,793,808–153,795,045 | 177.4 kb | Distal (>10kb) Multiome | 733 | |
| chrX:153,875,415–153,875,856 | 96.1 kb | Distal (>10kb) Multiome | 847 | |
| chrX:153,878,887–153,879,684 | 92.6 kb | Distal (>10kb) Multiome | 235 | |
| chrX:153,927,955–153,928,728 | 43.4 kb | Distal (>10kb) Multiome | 711 | |
| chrX:153,934,763–153,935,658 | 36.7 kb | Distal (>10kb) Multiome | 446 | |
| chrX:153,970,377–153,970,637 | 546 bp | At TSS | 203 | |
| chrX:153,970,913–153,973,065 | 648 bp | At TSS Multiome | 857 | |
| chrX:154,097,040–154,098,161 | 126.0 kb | Distal (>10kb) Multiome | 537 | |
| chrX:154,136,648–154,137,146 | 165.1 kb | Distal (>10kb) Multiome | 391 |
Genomic view of the HCFC1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.