The protein encoded by this gene is a type B histone acetyltransferase (HAT) that is involved in the rapid acetylation of newly synthesized cytoplasmic histones, which are in turn imported into the nucleus for de novo deposition onto nascent DNA chains. Histone acetylation, particularly of histone H4, plays an important role in replication-dependent chromatin assembly. Specifically, this HAT can acetylate soluble but not nucleosomal histone H4 at lysines 5 and 12, and to a lesser degree, histone H2A at lysine 5. Alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Jun 2009]
Transcription factors with Perturb-seq knockdown data for HAT1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = HAT1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of HAT1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:171,687,283–171,688,178 | 234.9 kb | Distal (>10kb) Multiome | 886 | |
| chr2:171,893,197–171,894,662 | 28.1 kb | Distal (>10kb) Multiome | 909 | |
| chr2:171,922,015–171,923,029 | 34 bp | At TSS Multiome | 901 | |
| chr2:171,999,394–172,000,424 | 77.4 kb | Distal (>10kb) Multiome | 1019 | |
| chr2:172,080,964–172,081,603 | 158.8 kb | Distal (>10kb) Multiome | 101 | |
| chr2:172,084,336–172,086,019 | 162.9 kb | Distal (>10kb) Multiome | 903 | |
| chr2:172,086,500–172,087,497 | 164.5 kb | Distal (>10kb) Multiome | 254 | |
| chr2:172,101,429–172,103,305 | 180.4 kb | Distal (>10kb) Multiome | 953 | |
| chr2:172,106,181–172,106,692 | 184.0 kb | Distal (>10kb) Multiome | 308 | |
| chr2:172,131,690–172,132,350 | 209.5 kb | Distal (>10kb) Multiome | 102 | |
| chr2:172,172,453–172,173,020 | 250.2 kb | Distal (>10kb) Multiome | 628 |
Genomic view of the HAT1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.