This gene is a member of the 3-hydroxyacyl-CoA dehydrogenase gene family. The encoded protein functions in the mitochondrial matrix to catalyze the oxidation of straight-chain 3-hydroxyacyl-CoAs as part of the beta-oxidation pathway. Its enzymatic activity is highest with medium-chain-length fatty acids. Mutations in this gene cause one form of familial hyperinsulinemic hypoglycemia. The human genome contains a related pseudogene of this gene on chromosome 15. [provided by RefSeq, May 2010]
Transcription factors with Perturb-seq knockdown data for HADH. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = HADH upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of HADH, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:107,719,405–107,721,939 | 269.5 kb | Distal (>10kb) Multiome | 867 | |
| chr4:107,823,948–107,825,750 | 164.9 kb | Distal (>10kb) Multiome | 772 | |
| chr4:107,930,814–107,932,445 | 58.3 kb | Distal (>10kb) Multiome | 716 | |
| chr4:107,989,250–107,990,853 | 33 bp | At TSS Multiome | 836 | |
| chr4:108,135,343–108,136,048 | 145.8 kb | Distal (>10kb) Multiome | 249 | |
| chr4:108,166,123–108,169,630 | 176.9 kb | Distal (>10kb) Multiome | 688 | |
| chr4:108,171,178–108,173,760 | 183.2 kb | Distal (>10kb) Multiome | 615 |
Genomic view of the HADH locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.