Transcription factors with Perturb-seq knockdown data for H1-10-AS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = H1-10-AS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of H1-10-AS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:129,027,026–129,027,525 | 288.2 kb | Distal (>10kb) Multiome | 589 | |
| chr3:129,045,697–129,046,752 | 268.8 kb | Distal (>10kb) Multiome | 170 | |
| chr3:129,120,244–129,122,947 | 193.3 kb | Distal (>10kb) Multiome | 767 | |
| chr3:129,160,815–129,162,244 | 154.0 kb | Distal (>10kb) Multiome | 917 | |
| chr3:129,183,284–129,184,525 | 131.4 kb | Distal (>10kb) Multiome | 966 | |
| chr3:129,249,227–129,250,064 | 65.8 kb | Distal (>10kb) Multiome | 767 | |
| chr3:129,278,315–129,279,976 | 36.5 kb | Distal (>10kb) Multiome | 767 | |
| chr3:129,305,525–129,306,095 | 9.6 kb | Proximal (<10kb) Multiome | 342 | |
| chr3:129,312,917–129,313,831 | 1.6 kb | Proximal (<10kb) | 209 | |
| chr3:129,314,154–129,316,995 | 427 bp | At TSS Multiome | 949 | |
| chr3:129,343,720–129,344,497 | 28.6 kb | Distal (>10kb) Multiome | 346 | |
| chr3:129,344,512–129,344,822 | 29.3 kb | Distal (>10kb) Multiome | 58 | |
| chr3:129,399,193–129,399,868 | 84.2 kb | Distal (>10kb) Multiome | 625 | |
| chr3:129,428,173–129,429,050 | 113.3 kb | Distal (>10kb) Multiome | 504 | |
| chr3:129,439,426–129,440,695 | 124.7 kb | Distal (>10kb) Multiome | 875 | |
| chr3:129,605,081–129,607,497 | 291.5 kb | Distal (>10kb) Multiome | 686 |
Genomic view of the H1-10-AS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.