GTP-binding proteins, or G proteins, constitute a superfamily capable of binding GTP or GDP. G proteins are activated by binding GTP and are inactivated by hydrolyzing GTP to GDP. This general mechanism enables G proteins to perform a wide range of biologic activities.[supplied by OMIM, Jan 2003]
Transcription factors with Perturb-seq knockdown data for GTPBP2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GTPBP2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GTPBP2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:43,368,714–43,370,143 | 259.5 kb | Distal (>10kb) Multiome | 909 | |
| chr6:43,426,936–43,428,340 | 201.5 kb | Distal (>10kb) Multiome | 919 | |
| chr6:43,454,362–43,454,991 | 174.4 kb | Distal (>10kb) Multiome | 686 | |
| chr6:43,477,347–43,478,043 | 151.6 kb | Distal (>10kb) Multiome | 747 | |
| chr6:43,506,605–43,507,204 | 122.3 kb | Distal (>10kb) Multiome | 474 | |
| chr6:43,509,337–43,511,016 | 118.8 kb | Distal (>10kb) Multiome | 734 | |
| chr6:43,516,463–43,517,515 | 112.2 kb | Distal (>10kb) Multiome | 904 | |
| chr6:43,575,269–43,576,483 | 53.1 kb | Distal (>10kb) Multiome | 1044 | |
| chr6:43,625,568–43,626,341 | 2.8 kb | Proximal (<10kb) | 90 | |
| chr6:43,628,488–43,630,447 | 1.0 kb | Proximal (<10kb) Multiome | 1157 | |
| chr6:43,635,496–43,636,104 | 6.7 kb | Proximal (<10kb) Multiome | 941 | |
| chr6:43,644,712–43,645,902 | 16.2 kb | Distal (>10kb) Multiome | 255 | |
| chr6:43,667,273–43,667,900 | 38.2 kb | Distal (>10kb) Multiome | 625 | |
| chr6:43,667,997–43,668,873 | 39.3 kb | Distal (>10kb) Multiome | 664 | |
| chr6:43,695,239–43,695,940 | 66.5 kb | Distal (>10kb) Multiome | 207 | |
| chr6:43,702,335–43,703,403 | 73.8 kb | Distal (>10kb) Multiome | 713 | |
| chr6:43,706,840–43,708,370 | 78.8 kb | Distal (>10kb) Multiome | 307 | |
| chr6:43,739,421–43,740,065 | 110.6 kb | Distal (>10kb) Multiome | 175 | |
| chr6:43,769,188–43,772,162 | 140.8 kb | Distal (>10kb) Multiome | 1112 | |
| chr6:43,774,651–43,775,250 | 145.8 kb | Distal (>10kb) Multiome | 440 | |
| chr6:43,926,273–43,928,465 | 298.1 kb | Distal (>10kb) Multiome | 1000 |
Genomic view of the GTPBP2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.