Enables RNA polymerase III general transcription initiation factor activity and histone H3K14 acetyltransferase activity. Predicted to be involved in 5S class rRNA transcription by RNA polymerase III; tRNA transcription by RNA polymerase III; and transcription initiation at RNA polymerase III promoter. Located in mitochondrion and nucleoplasm. Part of transcription factor TFIIIC complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for GTF3C4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GTF3C4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GTF3C4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:132,409,879–132,410,471 | 260.4 kb | Distal (>10kb) Multiome | 293 | |
| chr9:132,411,065–132,411,553 | 259.2 kb | Distal (>10kb) Multiome | 342 | |
| chr9:132,582,095–132,582,589 | 88.2 kb | Distal (>10kb) Multiome | 938 | |
| chr9:132,669,038–132,669,256 | 1.2 kb | Proximal (<10kb) | 14 | |
| chr9:132,669,401–132,670,935 | 160 bp | At TSS Multiome | 1040 | |
| chr9:132,770,159–132,770,672 | 100.0 kb | Distal (>10kb) Multiome | 385 | |
| chr9:132,794,730–132,795,358 | 124.5 kb | Distal (>10kb) Multiome HiCAR | 159 | |
| chr9:132,877,859–132,878,978 | 208.0 kb | Distal (>10kb) Multiome | 676 | |
| chr9:132,944,084–132,945,377 | 274.3 kb | Distal (>10kb) Multiome | 983 |
Genomic view of the GTF3C4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.