GTF2H4

general transcription factor IIH subunit 4 | P52, TFB2, TFIIH

Enables RNA polymerase II general transcription initiation factor activity. Involved in transcription by RNA polymerase II. Located in nuclear speck. Part of core TFIIH complex portion of holo TFIIH complex and transcription factor TFIID complex. [provided by Alliance of Genome Resources, Jul 2025]

Member of: DE-1 Developmental clusters: GC1

Biological processes 21 terms

ATPase activator activity (GO:0001671)DNA repair (GO:0006281)RNA polymerase II general transcription initiation factor activity (GO:0016251)core TFIIH complex portion of holo TFIIH complex (GO:0000438)double-stranded DNA binding (GO:0003690)nuclear speck (GO:0016607)nucleoplasm (GO:0005654)nucleotide-excision repair (GO:0006289)nucleotide-excision repair (GO:0006289)nucleotide-excision repair (GO:0006289)nucleus (GO:0005634)nucleus (GO:0005634)protein binding (GO:0005515)transcription by RNA polymerase II (GO:0006366)transcription by RNA polymerase II (GO:0006366)transcription factor TFIID complex (GO:0005669)transcription factor TFIIH core complex (GO:0000439)transcription factor TFIIH core complex (GO:0000439)transcription factor TFIIH holo complex (GO:0005675)transcription factor TFIIH holo complex (GO:0005675)transcription initiation at RNA polymerase II promoter (GO:0006367)

Expression (TPM)

TFs regulating GTF2H4 0 TFs

Transcription factors with Perturb-seq knockdown data for GTF2H4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GTF2H4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to GTF2H4

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GTF2H4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr6:30,614,393–30,615,939	293.0 kb	Distal (>10kb) Multiome	837
chr6:30,616,770–30,618,155	290.7 kb	Distal (>10kb) Multiome	1072
chr6:30,626,560–30,627,206	281.4 kb	Distal (>10kb) Multiome	802
chr6:30,646,505–30,648,035	260.9 kb	Distal (>10kb) Multiome	961
chr6:30,672,571–30,673,266	235.2 kb	Distal (>10kb) Multiome	812
chr6:30,679,032–30,679,479	229.0 kb	Distal (>10kb) Multiome	603
chr6:30,686,268–30,688,032	221.0 kb	Distal (>10kb) Multiome	801
chr6:30,690,445–30,691,240	217.3 kb	Distal (>10kb) Multiome	644
chr6:30,716,986–30,717,874	190.7 kb	Distal (>10kb) Multiome	1059
chr6:30,719,428–30,720,577	188.0 kb	Distal (>10kb) Multiome	724
chr6:30,721,307–30,722,103	186.7 kb	Distal (>10kb) Multiome	872
chr6:30,725,731–30,726,564	182.0 kb	Distal (>10kb) Multiome	478
chr6:30,740,996–30,745,094	165.5 kb	Distal (>10kb) Multiome	1233
chr6:30,763,647–30,765,193	143.8 kb	Distal (>10kb) Multiome	850
chr6:30,880,638–30,881,295	27.3 kb	Distal (>10kb) Multiome	124
chr6:30,882,560–30,883,422	25.3 kb	Distal (>10kb) Multiome	308
chr6:30,883,625–30,885,122	23.8 kb	Distal (>10kb) Multiome	538
chr6:30,907,770–30,908,494	120 bp	At TSS Multiome	1005
chr6:30,913,674–30,914,800	6.0 kb	Proximal (<10kb) Multiome	944
chr6:30,915,583–30,915,794	7.4 kb	Proximal (<10kb)	146
chr6:30,942,475–30,943,087	34.6 kb	Distal (>10kb) Multiome	300
chr6:30,955,192–30,955,975	47.5 kb	Distal (>10kb) Multiome	524
chr6:31,157,467–31,159,255	250.2 kb	Distal (>10kb) Multiome	740
chr6:31,171,796–31,173,419	263.8 kb	Distal (>10kb) Multiome	178

Genome Browser

Genomic view of the GTF2H4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.