Enables nuclear thyroid hormone receptor binding activity. Involved in positive regulation of DNA-templated transcription and transcription initiation at RNA polymerase II promoter. Located in nucleoplasm. Part of transcription factor TFIIH core complex and transcription factor TFIIH holo complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for GTF2H1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GTF2H1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GTF2H1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:18,105,744–18,106,263 | 216.2 kb | Distal (>10kb) Multiome | 873 | |
| chr11:18,318,016–18,318,522 | 4.1 kb | Proximal (<10kb) Multiome | 49 | |
| chr11:18,321,766–18,322,926 | 46 bp | At TSS Multiome | 1044 | |
| chr11:18,393,759–18,396,665 | 73.9 kb | Distal (>10kb) Multiome | 1203 | |
| chr11:18,526,292–18,527,325 | 204.6 kb | Distal (>10kb) Multiome | 1012 | |
| chr11:18,588,293–18,589,047 | 266.4 kb | Distal (>10kb) Multiome | 837 |
Genomic view of the GTF2H1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.