Predicted to enable RNA polymerase II general transcription initiation factor activity. Involved in positive regulation of transcription by RNA polymerase II; transcription elongation by RNA polymerase II; and transcription initiation at RNA polymerase II promoter. Located in microtubule cytoskeleton and nucleoplasm. Part of transcription factor TFIIF complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for GTF2F2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GTF2F2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GTF2F2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr13:44,917,543–44,919,062 | 202.4 kb | Distal (>10kb) Multiome | 1018 | |
| chr13:44,989,032–44,989,887 | 131.0 kb | Distal (>10kb) Multiome | 724 | |
| chr13:45,048,778–45,049,467 | 71.3 kb | Distal (>10kb) Multiome | 140 | |
| chr13:45,120,138–45,120,985 | 39 bp | At TSS Multiome | 723 | |
| chr13:45,249,481–45,250,367 | 129.4 kb | Distal (>10kb) Multiome | 120 | |
| chr13:45,310,992–45,312,067 | 190.9 kb | Distal (>10kb) Multiome HiCAR | 340 | |
| chr13:45,340,420–45,342,118 | 220.9 kb | Distal (>10kb) Multiome | 982 | |
| chr13:45,369,205–45,369,799 | 249.0 kb | Distal (>10kb) Multiome | 26 | |
| chr13:45,370,842–45,371,300 | 250.6 kb | Distal (>10kb) Multiome | 284 | |
| chr13:45,396,133–45,396,998 | 276.2 kb | Distal (>10kb) Multiome | 148 | |
| chr13:45,417,648–45,418,935 | 297.9 kb | Distal (>10kb) Multiome | 793 |
Genomic view of the GTF2F2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.