The general transcription factor IIE (TFIIE) is part of the RNA polymerase II transcription initiation complex, recruiting TFIIH and being essential for promoter clearance by RNA polymerase II. TFIIE is a heterodimer (and sometimes heterotetramer) of alpha and beta subunits. The protein encoded by this gene represents the beta subunit of TFIIE. [provided by RefSeq, Jan 2017]
Transcription factors with Perturb-seq knockdown data for GTF2E2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GTF2E2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GTF2E2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:28,700,738–28,702,456 | 1956.7 kb | Distal (>10kb) Multiome HiCAR | 728 | |
| chr8:30,382,832–30,383,366 | 275.3 kb | Distal (>10kb) Multiome | 188 | |
| chr8:30,383,830–30,385,512 | 273.7 kb | Distal (>10kb) Multiome | 578 | |
| chr8:30,423,017–30,423,578 | 234.8 kb | Distal (>10kb) Multiome | 306 | |
| chr8:30,442,133–30,442,945 | 215.6 kb | Distal (>10kb) Multiome | 264 | |
| chr8:30,541,211–30,542,932 | 116.6 kb | Distal (>10kb) Multiome | 253 | |
| chr8:30,555,639–30,556,644 | 102.2 kb | Distal (>10kb) Multiome | 396 | |
| chr8:30,657,598–30,658,716 | 1 bp | At TSS Multiome | 834 | |
| chr8:30,727,108–30,728,427 | 69.6 kb | Distal (>10kb) Multiome | 986 | |
| chr8:30,743,665–30,744,537 | 86.0 kb | Distal (>10kb) Multiome | 789 | |
| chr8:30,811,955–30,813,256 | 154.5 kb | Distal (>10kb) Multiome | 824 | |
| chr8:30,817,124–30,817,779 | 159.2 kb | Distal (>10kb) Multiome | 166 | |
| chr8:30,911,618–30,912,683 | 253.9 kb | Distal (>10kb) Multiome | 460 |
Genomic view of the GTF2E2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.