Enables tRNA-queuosine(34) beta-mannosyltransferase activity. Involved in regulation of translation and tRNA modification. Located in nucleus. Is active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for GTDC1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GTDC1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GTDC1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:144,324,542–144,324,957 | 7.6 kb | Proximal (<10kb) | 50 | |
| chr2:144,331,548–144,333,361 | 34 bp | At TSS Multiome | 956 | |
| chr2:144,334,670–144,334,873 | 2.2 kb | Proximal (<10kb) | 35 | |
| chr2:144,443,951–144,446,058 | 112.9 kb | Distal (>10kb) Multiome | 395 | |
| chr2:144,522,700–144,524,831 | 191.9 kb | Distal (>10kb) Multiome | 591 | |
| chr2:144,567,700–144,568,188 | 235.4 kb | Distal (>10kb) Multiome | 127 |
Genomic view of the GTDC1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.