This gene encodes a protein that is involved as a negative regulator of GSK3-beta in the Wnt signaling pathway. The encoded protein may play a role in the retinoic acid signaling pathway by regulating the functional interactions between GSK3-beta, beta-catenin and cyclin D1, and it regulates the beta-catenin/N-cadherin pool. The encoded protein contains a GSK3-beta interacting domain (GID) in its C-terminus, which is similar to the GID of Axin. The protein also contains an evolutionarily conserved RII-binding domain, which facilitates binding with protein kinase-A and GSK3-beta, enabling its role as an A-kinase anchoring protein. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2012]
Transcription factors with Perturb-seq knockdown data for GSKIP. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GSKIP upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GSKIP, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:96,191,842–96,192,712 | 171.3 kb | Distal (>10kb) Multiome | 49 | |
| chr14:96,362,070–96,362,551 | 973 bp | At TSS | 276 | |
| chr14:96,362,703–96,364,312 | 110 bp | At TSS Multiome | 728 | |
| chr14:96,391,216–96,392,835 | 28.4 kb | Distal (>10kb) Multiome | 787 | |
| chr14:96,461,283–96,462,546 | 98.5 kb | Distal (>10kb) Multiome | 392 | |
| chr14:96,501,754–96,503,092 | 138.8 kb | Distal (>10kb) Multiome | 986 | |
| chr14:96,583,910–96,584,894 | 220.9 kb | Distal (>10kb) Multiome | 345 | |
| chr14:96,592,395–96,593,217 | 229.2 kb | Distal (>10kb) Multiome | 226 |
Genomic view of the GSKIP locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.