This gene encodes a proline-rich protein with coiled coil domains that may be a subunit of a BRAF35-HDAC (BHC) histone deacetylase complex. This gene may function as an oncogene in breast cancer and enhanced expression of the encoded protein has been observed in breast cancer patients. [provided by RefSeq, May 2017]
Transcription factors with Perturb-seq knockdown data for GSE1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GSE1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GSE1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:85,328,109–85,329,876 | 226.2 kb | Distal (>10kb) Multiome | 593 | |
| chr16:85,334,820–85,335,647 | 220.8 kb | Distal (>10kb) Multiome | 468 | |
| chr16:85,436,751–85,437,266 | 118.8 kb | Distal (>10kb) Multiome | 353 | |
| chr16:85,535,241–85,535,831 | 20.4 kb | Distal (>10kb) Multiome | 750 | |
| chr16:85,553,072–85,554,550 | 2.5 kb | Proximal (<10kb) Multiome | 903 | |
| chr16:85,555,000–85,555,782 | 463 bp | At TSS Multiome | 640 | |
| chr16:85,556,561–85,557,310 | 932 bp | At TSS Multiome | 522 | |
| chr16:85,558,362–85,558,598 | 2.4 kb | Proximal (<10kb) | 239 | |
| chr16:85,566,304–85,567,587 | 11.0 kb | Distal (>10kb) Multiome | 510 | |
| chr16:85,607,130–85,608,222 | 51.7 kb | Distal (>10kb) Multiome | 299 | |
| chr16:85,610,026–85,614,714 | 58.4 kb | Distal (>10kb) Multiome | 1297 | |
| chr16:85,615,011–85,615,363 | 3.6 kb | Proximal (<10kb) | 564 | |
| chr16:85,615,828–85,616,352 | 60.1 kb | Distal (>10kb) Multiome | 462 | |
| chr16:85,688,630–85,689,464 | 133.1 kb | Distal (>10kb) Multiome | 742 | |
| chr16:85,750,820–85,751,405 | 195.2 kb | Distal (>10kb) Multiome | 317 | |
| chr16:85,798,853–85,800,250 | 243.7 kb | Distal (>10kb) Multiome | 921 | |
| chr16:85,898,542–85,899,371 | 343.0 kb | Distal (>10kb) Multiome | 380 |
Genomic view of the GSE1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.