Predicted to enable GTPase activator activity. Predicted to be active in cytoplasm and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for GRTP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GRTP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GRTP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr13:113,152,885–113,154,060 | 210.8 kb | Distal (>10kb) Multiome | 714 | |
| chr13:113,179,328–113,180,131 | 184.5 kb | Distal (>10kb) Multiome | 164 | |
| chr13:113,208,078–113,210,214 | 155.3 kb | Distal (>10kb) Multiome | 1103 | |
| chr13:113,296,598–113,297,816 | 67.0 kb | Distal (>10kb) Multiome | 1104 | |
| chr13:113,362,917–113,364,200 | at TSS | At TSS | 597 | |
| chr13:113,364,431–113,365,886 | 300 bp | At TSS | 227 | |
| chr13:113,393,735–113,394,451 | 30.0 kb | Distal (>10kb) Multiome | 576 | |
| chr13:113,397,604–113,398,329 | 33.8 kb | Distal (>10kb) Multiome | 76 | |
| chr13:113,489,310–113,491,886 | 126.8 kb | Distal (>10kb) Multiome | 791 | |
| chr13:113,584,313–113,585,542 | 220.5 kb | Distal (>10kb) Multiome | 559 | |
| chr13:113,652,944–113,653,751 | 289.2 kb | Distal (>10kb) Multiome | 168 |
Genomic view of the GRTP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.