Predicted to enable glutamate receptor binding activity. Predicted to be involved in several processes, including neurotransmitter receptor transport, endosome to postsynaptic membrane; positive regulation of AMPA glutamate receptor clustering; and positive regulation of excitatory postsynaptic potential. Predicted to act upstream of or within Notch signaling pathway; artery smooth muscle contraction; and positive regulation of blood pressure. Predicted to be located in dendritic shaft. Predicted to be active in glutamatergic synapse and postsynaptic density, intracellular component. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for GRIP2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GRIP2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GRIP2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:14,272,392–14,272,931 | 283.3 kb | Distal (>10kb) Multiome | 132 | |
| chr3:14,319,426–14,320,088 | 236.3 kb | Distal (>10kb) Multiome | 332 | |
| chr3:14,401,899–14,403,672 | 153.6 kb | Distal (>10kb) Multiome | 895 | |
| chr3:14,412,856–14,413,790 | 142.7 kb | Distal (>10kb) Multiome | 270 | |
| chr3:14,508,941–14,509,537 | 46.9 kb | Distal (>10kb) Multiome | 235 | |
| chr3:14,532,598–14,533,121 | 23.3 kb | Distal (>10kb) Multiome | 210 | |
| chr3:14,601,718–14,603,350 | 47.0 kb | Distal (>10kb) Multiome | 282 | |
| chr3:14,651,173–14,652,219 | 95.6 kb | Distal (>10kb) Multiome | 942 | |
| chr3:14,810,059–14,811,386 | 254.5 kb | Distal (>10kb) Multiome | 162 | |
| chr3:14,847,690–14,848,492 | 292.1 kb | Distal (>10kb) Multiome | 317 |
Genomic view of the GRIP2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.