Predicted to enable calcium channel activity. Predicted to be involved in apoptotic signaling pathway; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; and negative regulation of neuron apoptotic process. Predicted to act upstream of or within endoplasmic reticulum calcium ion homeostasis and negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway. Located in Golgi membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for GRINA. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GRINA upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GRINA, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:143,716,075–143,716,913 | 273.8 kb | Distal (>10kb) Multiome | 311 | |
| chr8:143,733,345–143,734,440 | 256.3 kb | Distal (>10kb) Multiome | 663 | |
| chr8:143,740,039–143,740,754 | 249.6 kb | Distal (>10kb) Multiome | 308 | |
| chr8:143,771,202–143,772,221 | 218.3 kb | Distal (>10kb) Multiome | 405 | |
| chr8:143,814,945–143,816,493 | 174.3 kb | Distal (>10kb) Multiome | 893 | |
| chr8:143,828,724–143,829,946 | 160.7 kb | Distal (>10kb) Multiome | 933 | |
| chr8:143,840,284–143,841,979 | 149.0 kb | Distal (>10kb) Multiome | 551 | |
| chr8:143,877,814–143,879,346 | 111.5 kb | Distal (>10kb) Multiome | 444 | |
| chr8:143,941,814–143,942,929 | 47.8 kb | Distal (>10kb) Multiome | 630 | |
| chr8:143,943,562–143,944,432 | 46.0 kb | Distal (>10kb) Multiome | 587 | |
| chr8:143,951,583–143,954,394 | 36.3 kb | Distal (>10kb) Multiome | 943 | |
| chr8:143,972,817–143,973,908 | 16.5 kb | Distal (>10kb) Multiome | 436 | |
| chr8:143,976,288–143,977,568 | 13.1 kb | Distal (>10kb) Multiome | 738 | |
| chr8:143,982,489–143,982,715 | 7.4 kb | Proximal (<10kb) | 203 | |
| chr8:143,989,521–143,991,038 | 53 bp | At TSS Multiome | 596 | |
| chr8:144,049,063–144,051,761 | 60.6 kb | Distal (>10kb) Multiome | 342 | |
| chr8:144,060,259–144,061,087 | 70.7 kb | Distal (>10kb) Multiome | 727 | |
| chr8:144,078,142–144,079,235 | 88.6 kb | Distal (>10kb) Multiome | 912 | |
| chr8:144,082,187–144,083,105 | 92.5 kb | Distal (>10kb) Multiome | 763 | |
| chr8:144,094,454–144,095,491 | 104.9 kb | Distal (>10kb) Multiome HiCAR | 798 | |
| chr8:144,103,485–144,105,242 | 114.3 kb | Distal (>10kb) Multiome | 1033 | |
| chr8:144,108,038–144,108,663 | 118.3 kb | Distal (>10kb) Multiome | 137 | |
| chr8:144,137,565–144,138,500 | 147.7 kb | Distal (>10kb) Multiome | 817 | |
| chr8:144,146,820–144,149,073 | 157.9 kb | Distal (>10kb) Multiome | 790 | |
| chr8:144,266,293–144,267,098 | 276.4 kb | Distal (>10kb) Multiome | 162 |
Genomic view of the GRINA locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.