This gene encodes a member of the N-methyl-D-aspartate (NMDA) receptor family within the ionotropic glutamate receptor superfamily. The encoded protein is a subunit of the NMDA receptor ion channel which acts as an agonist binding site for glutamate. The NMDA receptors mediate a slow calcium-permeable component of excitatory synaptic transmission in the central nervous system. The NMDA receptors are heterotetramers of seven genetically encoded, differentially expressed subunits including NR1 (GRIN1), NR2 (GRIN2A, GRIN2B, GRIN2C, or GRIN2D) and NR3 (GRIN3A or GRIN3B). The early expression of this gene in development suggests a role in brain development, circuit formation, synaptic plasticity, and cellular migration and differentiation. Naturally occurring mutations within this gene are associated with neurodevelopmental disorders including autism spectrum disorder, attention deficit hyperactivity disorder, epilepsy, and schizophrenia. [provided by RefSeq, Aug 2017]
Transcription factors with Perturb-seq knockdown data for GRIN2B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GRIN2B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GRIN2B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:13,278,080–13,278,892 | 703.1 kb | Distal (>10kb) Multiome HiCAR | 312 | |
| chr12:13,727,653–13,728,110 | 253.7 kb | Distal (>10kb) Multiome | 125 | |
| chr12:13,748,969–13,750,014 | 232.0 kb | Distal (>10kb) Multiome | 143 | |
| chr12:13,799,351–13,800,064 | 181.8 kb | Distal (>10kb) Multiome | 61 | |
| chr12:13,980,278–13,981,096 | 505 bp | At TSS | 166 | |
| chr12:13,981,328–13,982,520 | 505 bp | At TSS Multiome | 194 | |
| chr12:14,257,545–14,258,843 | 276.3 kb | Distal (>10kb) Multiome | 936 | |
| chr12:14,259,910–14,261,390 | 278.5 kb | Distal (>10kb) Multiome | 592 |
Genomic view of the GRIN2B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.