Members of the G protein-coupled receptor family, such as GPR176, are cell surface receptors involved in responses to hormones, growth factors, and neurotransmitters (Hata et al., 1995 [PubMed 7893747]).[supplied by OMIM, Jul 2008]
Transcription factors with Perturb-seq knockdown data for GPR176. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GPR176 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GPR176, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:39,782,369–39,782,987 | 137.6 kb | Distal (>10kb) Multiome HiCAR | 737 | |
| chr15:39,844,965–39,845,763 | 74.8 kb | Distal (>10kb) Multiome | 26 | |
| chr15:39,888,792–39,889,226 | 31.3 kb | Distal (>10kb) Multiome | 62 | |
| chr15:39,919,909–39,920,497 | at TSS | At TSS | 344 | |
| chr15:39,920,609–39,921,284 | 677 bp | At TSS Multiome | 707 | |
| chr15:39,933,904–39,934,437 | 13.8 kb | Distal (>10kb) Multiome | 698 | |
| chr15:40,038,862–40,039,388 | 118.9 kb | Distal (>10kb) Multiome | 750 | |
| chr15:40,108,639–40,109,491 | 188.8 kb | Distal (>10kb) Multiome | 798 | |
| chr15:40,160,791–40,161,326 | 240.7 kb | Distal (>10kb) Multiome | 762 |
Genomic view of the GPR176 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.