Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Located in plasma membrane. Part of receptor complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for GPR160. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GPR160 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GPR160, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:169,764,381–169,765,564 | 272.9 kb | Distal (>10kb) Multiome | 782 | |
| chr3:169,769,273–169,770,082 | 268.4 kb | Distal (>10kb) Multiome | 566 | |
| chr3:169,771,800–169,773,839 | 266.0 kb | Distal (>10kb) Multiome | 1077 | |
| chr3:169,811,873–169,814,235 | 225.4 kb | Distal (>10kb) Multiome | 581 | |
| chr3:169,966,015–169,967,550 | 71.2 kb | Distal (>10kb) Multiome | 1017 | |
| chr3:170,037,354–170,039,248 | 12 bp | At TSS Multiome | 804 | |
| chr3:170,040,096–170,040,615 | 2.1 kb | Proximal (<10kb) | 56 | |
| chr3:170,180,833–170,182,100 | 143.7 kb | Distal (>10kb) Multiome | 813 | |
| chr3:170,221,926–170,223,285 | 184.4 kb | Distal (>10kb) Multiome | 847 |
Genomic view of the GPR160 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.