Transcription factors with Perturb-seq knockdown data for GPALPP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GPALPP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GPALPP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr13:44,764,894–44,765,379 | 224.3 kb | Distal (>10kb) Multiome | 143 | |
| chr13:44,917,543–44,919,062 | 71.5 kb | Distal (>10kb) Multiome | 1018 | |
| chr13:44,989,032–44,989,887 | 47 bp | At TSS Multiome | 724 | |
| chr13:45,048,778–45,049,467 | 59.6 kb | Distal (>10kb) Multiome | 140 | |
| chr13:45,120,138–45,120,985 | 131.0 kb | Distal (>10kb) Multiome | 723 | |
| chr13:45,249,481–45,250,367 | 260.3 kb | Distal (>10kb) Multiome | 120 |
Genomic view of the GPALPP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.