This gene encodes a trafficking membrane protein which transports proteins among the medial- and trans-Golgi compartments. Due to its chromosomal location and trafficking function, this gene may be involved in familial essential hypertension. [provided by RefSeq, Mar 2016]
Transcription factors with Perturb-seq knockdown data for GOSR2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GOSR2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GOSR2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:46,741,863–46,742,381 | 181.1 kb | Distal (>10kb) Multiome | 64 | |
| chr17:46,770,710–46,773,968 | 151.3 kb | Distal (>10kb) Multiome | 1101 | |
| chr17:46,785,507–46,786,271 | 137.2 kb | Distal (>10kb) Multiome | 111 | |
| chr17:46,818,301–46,820,276 | 103.7 kb | Distal (>10kb) Multiome | 471 | |
| chr17:46,820,873–46,822,625 | 100.7 kb | Distal (>10kb) Multiome | 430 | |
| chr17:46,850,945–46,852,297 | 71.7 kb | Distal (>10kb) Multiome | 470 | |
| chr17:46,922,775–46,923,450 | 94 bp | At TSS Multiome | 986 | |
| chr17:47,099,846–47,100,680 | 177.1 kb | Distal (>10kb) Multiome | 574 | |
| chr17:47,188,797–47,189,938 | 266.3 kb | Distal (>10kb) Multiome | 1050 |
Genomic view of the GOSR2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.