Involved in positive regulation of canonical NF-kappaB signal transduction. Located in endoplasmic reticulum. Part of protein-containing complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for GOLT1B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GOLT1B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GOLT1B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:21,369,286–21,369,990 | 132.1 kb | Distal (>10kb) Multiome | 118 | |
| chr12:21,437,461–21,438,474 | 64.0 kb | Distal (>10kb) Multiome | 804 | |
| chr12:21,500,928–21,502,428 | 77 bp | At TSS Multiome | 804 | |
| chr12:21,527,079–21,528,319 | 26.0 kb | Distal (>10kb) Multiome HiCAR | 422 | |
| chr12:21,656,935–21,658,449 | 156.1 kb | Distal (>10kb) Multiome | 715 | |
| chr12:21,774,351–21,775,580 | 273.1 kb | Distal (>10kb) Multiome | 443 |
Genomic view of the GOLT1B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.