The Golgi apparatus, which participates in glycosylation and transport of proteins and lipids in the secretory pathway, consists of a series of stacked cisternae (flattened membrane sacs). Interactions between the Golgi and microtubules are thought to be important for the reorganization of the Golgi after it fragments during mitosis. This gene encodes one of the golgins, a family of proteins localized to the Golgi. This protein has been postulated to play a role in Rab6-regulated membrane-tethering events in the Golgi apparatus. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Feb 2010]
Transcription factors with Perturb-seq knockdown data for GOLGA4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GOLGA4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GOLGA4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:36,943,704–36,946,013 | 298.6 kb | Distal (>10kb) Multiome | 388 | |
| chr3:36,965,264–36,965,767 | 277.6 kb | Distal (>10kb) Multiome | 89 | |
| chr3:37,175,555–37,176,875 | 66.9 kb | Distal (>10kb) Multiome | 907 | |
| chr3:37,242,726–37,244,363 | 96 bp | At TSS Multiome | 969 | |
| chr3:37,451,532–37,454,321 | 208.9 kb | Distal (>10kb) Multiome | 422 | |
| chr3:37,504,384–37,505,247 | 261.6 kb | Distal (>10kb) Multiome | 181 | |
| chr3:37,531,867–37,532,817 | 289.2 kb | Distal (>10kb) Multiome | 142 |
Genomic view of the GOLGA4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.