The Golgi apparatus, which participates in glycosylation and transport of proteins and lipids in the secretory pathway, consists of a series of stacked cisternae (flattened membrane sacs). Interactions between the Golgi and microtubules are thought to be important for the reorganization of the Golgi after it fragments during mitosis. This gene encodes one of the golgins, a family of proteins localized to the Golgi. This encoded protein is associated with Sjogren's syndrome. [provided by RefSeq, Feb 2010]
Transcription factors with Perturb-seq knockdown data for GOLGA1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GOLGA1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GOLGA1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:124,769,647–124,772,472 | 169.6 kb | Distal (>10kb) Multiome | 1006 | |
| chr9:124,776,976–124,778,058 | 163.7 kb | Distal (>10kb) Multiome | 349 | |
| chr9:124,779,329–124,780,041 | 161.4 kb | Distal (>10kb) Multiome | 260 | |
| chr9:124,810,709–124,811,373 | 130.1 kb | Distal (>10kb) Multiome | 209 | |
| chr9:124,839,680–124,840,329 | 101.2 kb | Distal (>10kb) Multiome | 218 | |
| chr9:124,852,683–124,853,882 | 87.9 kb | Distal (>10kb) Multiome | 666 | |
| chr9:124,855,555–124,856,920 | 84.8 kb | Distal (>10kb) Multiome | 402 | |
| chr9:124,861,378–124,862,662 | 79.0 kb | Distal (>10kb) Multiome | 947 | |
| chr9:124,868,442–124,869,814 | 72.0 kb | Distal (>10kb) Multiome | 849 | |
| chr9:124,940,496–124,941,902 | 4 bp | At TSS Multiome | 979 | |
| chr9:125,142,890–125,144,084 | 202.5 kb | Distal (>10kb) Multiome | 723 | |
| chr9:125,189,173–125,190,290 | 248.8 kb | Distal (>10kb) Multiome | 830 | |
| chr9:125,199,947–125,201,039 | 259.5 kb | Distal (>10kb) Multiome | 866 | |
| chr9:125,240,934–125,242,115 | 300.4 kb | Distal (>10kb) Multiome | 974 |
Genomic view of the GOLGA1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.