The GNL1 gene, identified in the human major histocompatibility complex class I region, shows a high degree of similarity with its mouse counterpart. The GNL1 gene is located less than 2 kb centromeric to HLA-E, in the same transcriptional orientation. GNL1 is telomeric to HLA-B and HLA-C. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for GNL1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GNL1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GNL1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:30,259,131–30,260,199 | 296.5 kb | Distal (>10kb) Multiome | 475 | |
| chr6:30,325,606–30,327,611 | 229.1 kb | Distal (>10kb) Multiome | 1043 | |
| chr6:30,344,843–30,345,715 | 210.8 kb | Distal (>10kb) Multiome | 892 | |
| chr6:30,357,696–30,358,238 | 198.2 kb | Distal (>10kb) Multiome | 207 | |
| chr6:30,466,230–30,466,713 | 89.5 kb | Distal (>10kb) Multiome | 369 | |
| chr6:30,489,117–30,490,512 | 65.8 kb | Distal (>10kb) Multiome HiCAR | 750 | |
| chr6:30,516,006–30,516,707 | 39.7 kb | Distal (>10kb) Multiome | 739 | |
| chr6:30,555,407–30,557,765 | 554 bp | At TSS Multiome | 1161 | |
| chr6:30,570,822–30,571,949 | 15.3 kb | Distal (>10kb) Multiome | 1000 | |
| chr6:30,614,393–30,615,939 | 59.1 kb | Distal (>10kb) Multiome | 837 | |
| chr6:30,616,770–30,618,155 | 61.4 kb | Distal (>10kb) Multiome | 1072 | |
| chr6:30,626,560–30,627,206 | 70.8 kb | Distal (>10kb) Multiome | 802 | |
| chr6:30,646,505–30,648,035 | 91.2 kb | Distal (>10kb) Multiome | 961 | |
| chr6:30,672,571–30,673,266 | 116.9 kb | Distal (>10kb) Multiome | 812 | |
| chr6:30,679,032–30,679,479 | 123.1 kb | Distal (>10kb) Multiome | 603 | |
| chr6:30,686,268–30,688,032 | 131.2 kb | Distal (>10kb) Multiome | 801 | |
| chr6:30,690,445–30,691,240 | 134.9 kb | Distal (>10kb) Multiome | 644 | |
| chr6:30,716,986–30,717,874 | 161.4 kb | Distal (>10kb) Multiome | 1059 | |
| chr6:30,719,428–30,720,577 | 164.1 kb | Distal (>10kb) Multiome | 724 | |
| chr6:30,721,307–30,722,103 | 165.4 kb | Distal (>10kb) Multiome | 872 | |
| chr6:30,725,731–30,726,564 | 170.1 kb | Distal (>10kb) Multiome | 478 | |
| chr6:30,740,996–30,745,094 | 186.7 kb | Distal (>10kb) Multiome | 1233 | |
| chr6:30,763,647–30,765,193 | 208.3 kb | Distal (>10kb) Multiome | 850 |
Genomic view of the GNL1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.