This gene encodes one of the gamma subunits of a guanine nucleotide-binding protein. Such proteins are involved in signaling mechanisms across membranes. Various subunits forms heterodimers which then interact with the different signal molecules. [provided by RefSeq, Aug 2011]
Transcription factors with Perturb-seq knockdown data for GNG2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GNG2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GNG2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:51,093,327–51,096,214 | 765.4 kb | Distal (>10kb) Multiome HiCAR | 700 | |
| chr14:51,650,673–51,652,859 | 208.9 kb | Distal (>10kb) Multiome | 783 | |
| chr14:51,776,047–51,776,802 | 84.2 kb | Distal (>10kb) Multiome | 249 | |
| chr14:51,826,826–51,827,456 | 33.7 kb | Distal (>10kb) Multiome | 39 | |
| chr14:51,827,934–51,828,961 | 32.2 kb | Distal (>10kb) Multiome | 229 | |
| chr14:51,846,633–51,847,447 | 13.6 kb | Distal (>10kb) Multiome | 292 | |
| chr14:51,860,279–51,860,931 | at TSS | At TSS | 325 | |
| chr14:51,864,972–51,865,109 | 4.4 kb | Proximal (<10kb) | 13 | |
| chr14:51,865,785–51,866,442 | 5.2 kb | Proximal (<10kb) | 172 | |
| chr14:51,988,956–51,990,294 | 129.0 kb | Distal (>10kb) Multiome HiCAR | 755 | |
| chr14:52,067,674–52,070,026 | 208.6 kb | Distal (>10kb) Multiome | 507 |
Genomic view of the GNG2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.