GMEB2

glucocorticoid modulatory element binding protein 2 | KIAA1269, P79PIF, PIF79

This gene is a member of KDWK gene family. The product of this gene associates with GMEB1 protein, and the complex is essential for parvovirus DNA replication. Study of rat homolog implicates the role of this gene in modulation of transactivation by the glucocorticoid receptor bound to glucocorticoid response elements. This gene appears to use multiple polyadenylation sites. [provided by RefSeq, Jul 2008]

Member of: DE-6 DE-6.16

Biological processes 17 terms

DNA binding (GO:0003677)DNA-binding transcription activator activity, RNA polymerase II-specific (GO:0001228)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)chromatin (GO:0000785)cytoplasm (GO:0005737)cytosol (GO:0005829)identical protein binding (GO:0042802)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)positive regulation of transcription by RNA polymerase II (GO:0045944)protein binding (GO:0005515)sequence-specific DNA binding (GO:0043565)sequence-specific double-stranded DNA binding (GO:1990837)transcription by RNA polymerase II (GO:0006366)

Expression (TPM)

TFs regulating GMEB2 0 TFs

Transcription factors with Perturb-seq knockdown data for GMEB2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GMEB2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to GMEB2

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GMEB2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr20:63,409,631–63,410,124	217.2 kb	Distal (>10kb) Multiome	60
chr20:63,471,533–63,472,788	154.4 kb	Distal (>10kb) Multiome	219
chr20:63,488,166–63,488,632	138.6 kb	Distal (>10kb) Multiome	127
chr20:63,498,850–63,499,391	127.8 kb	Distal (>10kb) Multiome	232
chr20:63,519,657–63,521,677	106.5 kb	Distal (>10kb) Multiome	712
chr20:63,537,759–63,538,455	89.0 kb	Distal (>10kb) Multiome	823
chr20:63,552,551–63,554,733	73.5 kb	Distal (>10kb) Multiome	544
chr20:63,573,969–63,574,596	52.8 kb	Distal (>10kb) Multiome	551
chr20:63,626,480–63,627,647	77 bp	At TSS Multiome	982
chr20:63,641,266–63,642,913	15.0 kb	Distal (>10kb) Multiome	691
chr20:63,652,233–63,654,166	26.5 kb	Distal (>10kb) Multiome	1011
chr20:63,657,813–63,658,939	31.4 kb	Distal (>10kb) Multiome	1055
chr20:63,696,254–63,697,070	69.5 kb	Distal (>10kb) Multiome	458
chr20:63,707,489–63,708,488	80.9 kb	Distal (>10kb) Multiome	1008
chr20:63,737,573–63,741,470	112.6 kb	Distal (>10kb) Multiome	1098
chr20:63,775,216–63,775,997	148.4 kb	Distal (>10kb) Multiome	257
chr20:63,830,341–63,832,721	204.2 kb	Distal (>10kb) Multiome	628
chr20:63,846,273–63,846,790	219.4 kb	Distal (>10kb) Multiome	487
chr20:63,864,234–63,865,991	238.0 kb	Distal (>10kb) Multiome	1158
chr20:63,894,341–63,895,764	267.9 kb	Distal (>10kb) Multiome	791

Genome Browser

Genomic view of the GMEB2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.