The enzyme encoded by this gene is responsible for the catalysis and formation of S-lactoyl-glutathione from methylglyoxal condensation and reduced glutatione. Glyoxalase I is linked to HLA and is localized to 6p21.3-p21.1, between HLA and the centromere. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for GLO1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GLO1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GLO1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:37,705,006–37,706,173 | 997.5 kb | Distal (>10kb) Multiome HiCAR | 470 | |
| chr6:38,433,142–38,434,636 | 268.8 kb | Distal (>10kb) Multiome | 76 | |
| chr6:38,477,364–38,478,181 | 225.4 kb | Distal (>10kb) Multiome | 82 | |
| chr6:38,639,224–38,640,428 | 63.3 kb | Distal (>10kb) Multiome | 836 | |
| chr6:38,702,618–38,703,392 | 5 bp | At TSS Multiome | 886 |
Genomic view of the GLO1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.