Connexins, such as GJB7, are involved in the formation of gap junctions, intercellular conduits that directly connect the cytoplasms of contacting cells. Each gap junction channel is formed by docking of 2 hemichannels, each of which contains 6 connexin subunits (Sohl et al., 2003 [PubMed 12881038]).[supplied by OMIM, Mar 2008]
Transcription factors with Perturb-seq knockdown data for GJB7. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GJB7 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GJB7, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:87,151,562–87,152,822 | 177.1 kb | Distal (>10kb) Multiome | 359 | |
| chr6:87,154,802–87,156,695 | 173.8 kb | Distal (>10kb) Multiome | 1153 | |
| chr6:87,320,722–87,321,018 | 8.2 kb | Proximal (<10kb) | 41 | |
| chr6:87,322,367–87,323,025 | 6.7 kb | Proximal (<10kb) Multiome | 892 | |
| chr6:87,328,682–87,329,364 | at TSS | At TSS | 81 | |
| chr6:87,333,036–87,333,449 | 3.8 kb | Proximal (<10kb) | 111 | |
| chr6:87,336,313–87,336,729 | 7.1 kb | Proximal (<10kb) | 55 | |
| chr6:87,407,486–87,408,928 | 78.9 kb | Distal (>10kb) Multiome | 735 | |
| chr6:87,472,409–87,473,809 | 143.8 kb | Distal (>10kb) Multiome | 913 | |
| chr6:87,483,840–87,484,329 | 154.9 kb | Distal (>10kb) Multiome | 125 | |
| chr6:87,589,655–87,590,489 | 260.8 kb | Distal (>10kb) Multiome | 803 |
Genomic view of the GJB7 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.