Enables identical protein binding activity. Located in extracellular exosome. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for GIPC2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GIPC2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GIPC2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:77,681,742–77,684,058 | 296.1 kb | Distal (>10kb) Multiome | 1050 | |
| chr1:77,686,763–77,688,131 | 291.8 kb | Distal (>10kb) Multiome | 208 | |
| chr1:77,758,895–77,760,199 | 219.7 kb | Distal (>10kb) Multiome | 856 | |
| chr1:77,779,465–77,780,294 | 199.8 kb | Distal (>10kb) Multiome | 779 | |
| chr1:77,888,069–77,889,521 | 90.8 kb | Distal (>10kb) Multiome | 648 | |
| chr1:77,976,530–77,976,964 | 2.6 kb | Proximal (<10kb) | 75 | |
| chr1:77,978,065–77,980,001 | 302 bp | At TSS Multiome | 993 | |
| chr1:77,983,355–77,983,855 | 3.8 kb | Proximal (<10kb) | 37 | |
| chr1:78,045,313–78,046,896 | 66.7 kb | Distal (>10kb) Multiome | 583 | |
| chr1:78,053,169–78,053,569 | 7.2 kb | Proximal (<10kb) | 35 | |
| chr1:78,236,703–78,237,945 | 258.1 kb | Distal (>10kb) Multiome | 336 |
Genomic view of the GIPC2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.